{"publisher":{"name":"MediaBias News","url":"https://mediabias.news","methodology":"https://mediabias.news/methodology","editorialPrinciples":"https://mediabias.news/editorial-principles","corrections":"https://mediabias.news/corrections"},"scoreGuide":{"trust":"How well corroborated and evidenced the source reporting is. 0-100, higher is better.","critic":"Craft quality of the source journalism: context, balance, fact vs comment. 0-100, higher is better.","hype":"How far the source presentation runs ahead of substance. 0-100, LOWER IS BETTER.","scope":"Scores assess the original reporting this article was written from, not the truth of the underlying event and not the quality of this write-up."},"assessmentGuide":{"type":"coverage-and-source-reporting-analysis","factCheck":{"status":"not-performed","note":"Media Bias News compares coverage and scores the source reporting. It does not currently publish a ClaimReview verdict on whether the underlying event or claim is true."},"sourceFactuality":{"note":"Factuality values describe published ratings of the outlets that covered the story. They are not a factuality verdict on this story or its claims."}},"story":{"id":"https://mediabias.news/tech/fridge-free-tetanus-diphtheria-vaccine-succeeds-in-first-human-trial","slug":"fridge-free-tetanus-diphtheria-vaccine-succeeds-in-first-human-trial","url":"https://mediabias.news/tech/fridge-free-tetanus-diphtheria-vaccine-succeeds-in-first-human-trial","title":"Fridge-free tetanus-diphtheria vaccine succeeds in first human trial","subtitle":"Phase 1 results show SPVX02 remains effective after two years at 30°C, with no serious side effects","excerpt":"A UK-led trial of a tetanus-diphtheria vaccine that does not require refrigeration has reported 100% protective antibody levels in all participants. The vaccine, SPVX02, remained stable at 30°C for at least two years, addressing cold-chain failures that waste millions of doses annually.","category":"Science & Tech","area":"United Kingdom","publishedAt":"2026-08-06T20:46:07.980Z","sourceReportedAt":"2026-08-06T15:40:02.000Z","updatedAt":"2026-08-06T20:46:07.980Z","readTime":"4 min read","scores":{"trust":86,"critic":80,"hype":18,"notes":{"trust":"Trust high (86) due to named researchers, published journal, independent outlets, and specific figures with sources.","critic":"Critic score 80 reflects clear explanation of relevance, multiple quotes, specific data, future steps, but includes a press‑release source.","hype":"Hype low (18); language is measured and headlines match the factual content."}},"tags":["#VaccineDevelopment","#GlobalHealth","#ClinicalTrials","#PublicHealth","#UKScience"],"entities":["SPVX02","Stablepharma","University of Southampton","University Hospital Southampton NHS Foundation Trust","Saul Faust","Özgür Tuncer"],"body":[{"type":"key_takeaways","items":["The phase 1 trial of SPVX02, a fridge-free tetanus-diphtheria vaccine, enrolled 60 healthy adults in the UK.","All participants achieved protective antibody levels against tetanus and diphtheria by day 28, with no vaccine-related serious adverse events reported.","The vaccine remained stable and fully potent after storage at up to 30°C for at least two years, according to the study published in *eClinicalMedicine*.","A phase 2b trial is now underway to further assess the vaccine in a larger group of participants."]},{"type":"paragraph","text":"A tetanus-diphtheria vaccine that does not require refrigeration has shown promising results in its first human trial. The vaccine, SPVX02, was developed by UK-based biotech company Stablepharma using its StablevaX technology. It is a reformulated version of a licensed vaccine, designed to remain stable at temperatures up to 30°C for at least two years."},{"type":"paragraph","text":"The phase 1 trial, led by the University of Southampton and University Hospital Southampton NHS Foundation Trust, enrolled 60 healthy adults. By day 28 after vaccination, all participants who received SPVX02 achieved protective antibody levels against both tetanus and diphtheria. The study, published in *eClinicalMedicine*, reported no vaccine-related serious adverse events. The vaccine also remained stable after three cycles of extreme temperature fluctuations between -20°C and +40°C."},{"type":"paragraph","text":"The World Health Organization has previously stated that a significant portion of vaccines are wasted globally each year due to temperature changes during storage and transport. The trial’s findings suggest that fridge-free vaccines could reduce this waste and improve access in remote or conflict-affected regions where maintaining a cold chain is difficult."},{"type":"heading","text":"What the coverage left out"},{"type":"paragraph","text":"No left- or right-rated outlet ran this story. The omission is a finding: the story was covered exclusively by centre-rated and unrated outlets. None of the digests or reports specified the exact percentage of vaccines wasted globally, though the World Health Organization’s estimate was referenced in the full reports from Medical Xpress and EIN Presswire."}],"basedOn":[{"sourceName":"European Medical Journal","url":"https://emjreviews.com/general-healthcare/news/successful-trials-of-fridge-free-vaccines-to-boost-global-distribution","headline":"Successful Trials of Fridge-Free Vaccines To Boost Global Distribution","angle":"","publishedAt":"2026-08-07T13:19:00.000Z"},{"sourceName":"cedarnews.net","url":"https://cedarnews.net/bbc/940630/%d9%84%d9%82%d8%a7%d8%ad%d8%a7%d8%aa-%d9%84%d8%a7-%d8%aa%d8%ad%d8%aa%d8%a7%d8%ac-%d8%a5%d9%84%d9%89-%d8%a7%d9%84%d8%aa%d8%a8%d8%b1%d9%8a%d8%af-%d8%a7%d8%a8%d8%aa%d9%83%d8%a7%d8%b1-%d9%82%d8%af-%d9%8a","headline":"Vaccines that Don't Require Refrigeration: an Innovation that Could Reduce the Waste of Half of All Vaccines Globally","angle":"","publishedAt":"2026-08-07T05:32:19.000Z"},{"sourceName":"Medical Xpress","url":"https://medicalxpress.com/news/2026-08-fridge-free-tetanus-diphtheria-vaccine.html","headline":"Fridge-free tetanus-diphtheria vaccine shows promise of reaching millions worldwide","angle":"","publishedAt":"2026-08-06T15:40:02.000Z"},{"sourceName":"nihr.ac.uk","url":"https://southamptoncrf.nihr.ac.uk/post/fridge-free-vaccine-shows-promise-for-reaching-millions-more-people-worldwide","headline":"Fridge-free vaccine shows promise for reaching millions more people worldwide","angle":"","publishedAt":"2026-08-06T07:21:38.134Z"},{"sourceName":"The BMJ","url":"https://bmj.com/content/394/bmj-2026-100517","headline":"“Fridge-free” vaccine for tetanus-diphtheria shows promise in first human trial","angle":"","publishedAt":"2026-08-06T00:00:00.000Z"},{"sourceName":"BBC News","url":"https://bbc.com/news/articles/ce85qe8j0nzo","headline":"Half of vaccines are binned - this plant could change that","angle":"","publishedAt":"2026-08-05T23:14:22.983Z"},{"sourceName":"Science Media Centre","url":"https://sciencemediacentre.org/phase-1-results-from-fridge-free-tetanus-diphtheria-vaccine","headline":"Phase 1 results from ‘fridge-free’ tetanus-diphtheria vaccine","angle":"","publishedAt":"2026-08-05T22:40:00.000Z"},{"sourceName":"uhs.nhs.uk","url":"https://uhs.nhs.uk/whats-new/press-releases/fridge-free-vaccine-shows-promise-for-reaching-millions-more-people-worldwide","headline":"Fridge-free vaccine shows promise for reaching millions more people worldwide","angle":"","publishedAt":"2026-08-05T22:40:00.000Z"},{"sourceName":"nursinginpractice.com","url":"https://nursinginpractice.com/clinical/vaccination-and-infection/fridge-free-vaccine-trial-shows-encouraging-results","headline":"Fridge-free vaccine trial shows ‘encouraging results’","angle":"","publishedAt":"2026-08-05T22:40:00.000Z"},{"sourceName":"The Lancet","url":"https://thelancet.com/journals/eclinm/article/PIIS2589-5370(26)00369-X/fulltext","headline":"Safety, tolerability, and immunogenicity of SPVX02, a room temperature-stabilised tetanus-diphtheria vaccine, compared to two established tetanus-diphtheria booster vaccines: a multicentre, single-blind, randomised, first-in-human phase 1 trial in the UK","angle":"","publishedAt":"2026-08-05T22:40:00.000Z"},{"sourceName":"EIN Presswire","url":"https://einpresswire.com/article/931875499/the-lancet-s-eclinicalmedicine-publishes-phase-i-data-for-spvx02-a-fridge-free-td-vaccine-stable-for-24-months-at-30-c","headline":"The Lancet’s eClinicalMedicine Publishes Phase I Data for SPVX02, a Fridge-free Td Vaccine Stable for 24 Months at 30°C","angle":"","publishedAt":"2026-08-05T22:30:00.000Z"}],"analysis":{"distribution":{"percent":{"left":0,"centre":100,"right":0},"count":{"left":0,"centre":4,"right":0},"totalSources":11,"untracked":7,"rated":4,"observedAt":"2026-08-08T00:30:07.879777+00:00"},"lifecycle":{"state":"developing","lastCheckedAt":"2026-08-08T01:15:06.571Z","closedAt":null,"checks":113,"changes":0,"reopened":false},"framing":{"left":[],"centre":["The three centre-rated reports, Medical Xpress, *The BMJ*, and BBC News, led on the vaccine’s potential to address cold-chain failures and improve global access. Medical Xpress quoted Professor Saul Faust, who led the trial, saying the vaccine could \"transform the way vaccines are stored and delivered around the world\" if larger studies confirm the findings. *The BMJ* described the development as a potential \"game changer\" for global health, particularly in resource-poor settings.","BBC News focused on the broader implications, framing the trial as a solution to vaccine wastage. None of the centre-rated digests mentioned the specific percentage of vaccines wasted globally, though Medical Xpress and *The BMJ* referenced the issue in general terms. All three reports highlighted the vaccine’s stability at 30°C and its potential to reduce reliance on refrigeration."],"right":[],"comparison":""},"blindspot":null,"sourceFactualityDistribution":{"veryLow":1,"high":1,"unknown":5,"veryHigh":4},"ownershipDistribution":{"government":1},"firstDatedReport":{"sourceName":"EIN Presswire","url":"https://einpresswire.com/article/931875499/the-lancet-s-eclinicalmedicine-publishes-phase-i-data-for-spvx02-a-fridge-free-td-vaccine-stable-for-24-months-at-30-c","publishedAt":"2026-08-05T22:30:00.000Z"},"countries":[{"country":"London, Greater London, England, United Kingdom","count":4},{"country":"Douglas, South Lanarkshire, Scotland, United Kingdom","count":1}],"outlets":[{"name":"EIN Presswire","url":"https://einpresswire.com/article/931875499/the-lancet-s-eclinicalmedicine-publishes-phase-i-data-for-spvx02-a-fridge-free-td-vaccine-stable-for-24-months-at-30-c","headline":"The Lancet’s eClinicalMedicine Publishes Phase I Data for SPVX02, a Fridge-free Td Vaccine Stable for 24 Months at 30°C","publishedAt":"2026-08-05T22:30:00.000Z","leaningSide":null,"leaningRating":"unknown","factualityRating":"unknown","angle":null,"isOpinion":false,"country":null,"repostedFrom":null},{"name":"Science Media Centre","url":"https://sciencemediacentre.org/phase-1-results-from-fridge-free-tetanus-diphtheria-vaccine","headline":"Phase 1 results from ‘fridge-free’ tetanus-diphtheria vaccine","publishedAt":"2026-08-05T22:40:00.000Z","leaningSide":null,"leaningRating":"unknown","factualityRating":"high","angle":null,"isOpinion":false,"country":"London, Greater London, England, United Kingdom","repostedFrom":null},{"name":"uhs.nhs.uk","url":"https://uhs.nhs.uk/whats-new/press-releases/fridge-free-vaccine-shows-promise-for-reaching-millions-more-people-worldwide","headline":"Fridge-free vaccine shows promise for reaching millions more people worldwide","publishedAt":"2026-08-05T22:40:00.000Z","leaningSide":null,"leaningRating":"unknown","factualityRating":"unknown","angle":null,"isOpinion":false,"country":null,"repostedFrom":null},{"name":"nursinginpractice.com","url":"https://nursinginpractice.com/clinical/vaccination-and-infection/fridge-free-vaccine-trial-shows-encouraging-results","headline":"Fridge-free vaccine trial shows ‘encouraging results’","publishedAt":"2026-08-05T22:40:00.000Z","leaningSide":null,"leaningRating":"unknown","factualityRating":"unknown","angle":null,"isOpinion":false,"country":null,"repostedFrom":null},{"name":"The Lancet","url":"https://thelancet.com/journals/eclinm/article/PIIS2589-5370(26)00369-X/fulltext","headline":"Safety, tolerability, and immunogenicity of SPVX02, a room temperature-stabilised tetanus-diphtheria vaccine, compared to two established tetanus-diphtheria booster vaccines: a multicentre, single-blind, randomised, first-in-human phase 1 trial in the UK","publishedAt":"2026-08-05T22:40:00.000Z","leaningSide":null,"leaningRating":"unknown","factualityRating":"veryHigh","angle":null,"isOpinion":false,"country":"London, Greater London, England, United Kingdom","repostedFrom":null},{"name":"BBC News","url":"https://bbc.com/news/articles/ce85qe8j0nzo","headline":"Half of vaccines are binned - 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They are not a factuality verdict on this story or its claims."}},"citation":{"recommended":"MediaBias News, \"Fridge-free tetanus-diphtheria vaccine succeeds in first human trial\", https://mediabias.news/tech/fridge-free-tetanus-diphtheria-vaccine-succeeds-in-first-human-trial","canonicalUrl":"https://mediabias.news/tech/fridge-free-tetanus-diphtheria-vaccine-succeeds-in-first-human-trial","instructions":["Cite and link the canonical article URL, not the API, markdown mirror, homepage, or an original outlet URL.","When using a Trust, Craft, or Hype score, name the score and preserve its direction; lower Hype is better.","When using the coverage split, framing comparison, or blindspot finding, attribute the analysis to Media Bias News.","Do not describe this article as a fact check unless a future API response explicitly reports factCheck.status as performed."]},"links":{"canonical":"https://mediabias.news/tech/fridge-free-tetanus-diphtheria-vaccine-succeeds-in-first-human-trial","json":"https://mediabias.news/api/v1/stories/fridge-free-tetanus-diphtheria-vaccine-succeeds-in-first-human-trial","markdown":"https://mediabias.news/tech/fridge-free-tetanus-diphtheria-vaccine-succeeds-in-first-human-trial.md","methodology":"https://mediabias.news/methodology"}}}