Skip to the story
All stories

Shingrix vaccine may reduce heart disease and dementia risk

A study suggests the recombinant shingles vaccine offers protection against cardiovascular events and cognitive decline.

AI-assisted coverage comparison, editor-supervised · How this was made

Published
Shingrix vaccine may reduce heart disease and dementia risk

What this story says

  • The recombinant shingles vaccine Shingrix may offer protection against cardiovascular events, according to a study.
  • The vaccine was linked to a 24% lower risk of dementia in older adults in one analysis.
  • Researchers suggest the vaccine's adjuvant may cause beneficial changes in immune cells and the vascular endothelium.
  • The apparent cardiovascular benefit was mainly observed in the first 3.5 years after vaccination.

Who covered it

Left 0%(0)Centre 67%(4)Right 33%(2)

Percentages are shares of the 6 outlets carrying a published leaning rating. 1 of the 7 outlets we know ran this story carry no rating and are not counted in them. Coverage measured .

Trust

60/100

Craft

65/100

Hype

45/100

7 sources · methodology

A study suggests that the recombinant shingles vaccine, Shingrix, may offer protection against cardiovascular events and dementia. Research published in Nature Medicine indicated that individuals vaccinated with Shingrix experienced a nine percent reduction in cardiovascular disease burden over seven years compared to those who received the older Zostavax vaccine. This benefit was observed across several conditions, including a 10% reduction in coronary heart disease, a 12% reduction in heart failure, and a seven percent reduction in atrial fibrillation. Stroke outcomes were less clear, though a 12% lower burden was noted in men receiving Shingrix.

Another analysis, drawing on Medicare data and health records of over 500,000 adults, linked the Shingrix vaccine to a 24% lower risk of dementia in older adults. This study compared patients who received at least one dose of Shingrix with unvaccinated individuals over a four-year follow-up period. Dementia developed in 18.8% of vaccinated participants compared to 24.6% of those who were not vaccinated. The study authors noted that while the findings suggest a link, they cannot definitively prove cause and effect, and further clinical trials are needed.

Disagreement on dementia risk reduction

One study reported a 24% lower risk of dementia in older adults who received the Shingrix vaccine. Another report mentioned that the same vaccine group had a 17% lower risk of dementia over the follow-up period compared to the live vaccine group.

What the coverage left out

None of the centre-rated or right-rated reports mentioned the specific methodology used by Inside Precision Medicine, which involved comparing groups vaccinated in 2017 and 2018. The centre-rated reports did not mention the specific funding source for the Science Daily study, which was GlaxoSmithKline, the manufacturer of Shingrix. No reports mentioned the potential for repeated vaccination at regular intervals as suggested by the researchers in Inside Precision Medicine.

Still developing. We have re-checked which outlets are covering this 4 times, most recently on 26 Aug 2026, 10:45, and will add the sides that appear.

How other outlets pictured it

Which photograph to run is each newsroom’s own choice. The leaning beside a name is that outlet’s published rating, not a claim that the pictures divide along it. Every picture is shown from the outlet’s own server and links to the article it ran in.

Older adults who received the Shingrix shingles vaccine had a 24% lower risk of being diagnosed with dementia over four years. Credit: Shutterstock
Science DailyCentre

How each side covered it

Our own reading of the reporting listed below, written from the outlets’ articles rather than quoted from them. The reasoning is set out on our methodology page.

Left

0 rated outlets

No outlet rated left has run this story so far. We are still checking, and will say plainly if that does not change.

Centre

4 rated outlets

  • Centre-rated reports led on the potential cardiovascular benefits of the Shingrix vaccine. Inside Precision Medicine highlighted that the vaccine may offer protection against cardiovascular events, citing a nine percent reduction in cardiovascular disease burden and specific reductions in coronary heart disease, heart failure, and atrial fibrillation. Science Daily focused on the vaccine's link to a 24% lower risk of dementia, presenting it as adding to evidence of vaccination's neuroprotective benefits. New Scientist also noted the potential for reduced stroke and heart failure risk, while STAT reported on the vaccine's link to lower heart disease and dementia risk, calling it a 'natural experiment' by Oxford researchers.

Right

2 rated outlets

  • Right-rated reports focused on the dementia risk reduction associated with the Shingrix vaccine. The News described the vaccine as a 'game-changer' for lowering dementia risk in older adults. La Razón reported that a study of over 500,000 older people detected fewer cases of dementia among those vaccinated against herpes zoster, citing a 24% lower risk.

Questions about this coverage

How did the left and right cover Shingrix vaccine may reduce heart disease and dementia risk?
Of the 6 outlets on this story carrying a published leaning rating, 0% are rated left, 67% are rated centre, 33% are rated right. Those percentages are shares of the rated outlets, not of every outlet that ran it, which was 7. The sections above set out what each side emphasised, in its own terms.
Is Shingrix vaccine may reduce heart disease and dementia risk left or right?
Too few of the outlets on this story carry a published leaning rating to say. 6 of them do, and this site does not characterise a field under 12: at that size one newsroom filing moves the share by ten points. The percentages above are the count as it stands.
Is the coverage of Shingrix vaccine may reduce heart disease and dementia risk biased?
Shingrix vaccine may reduce heart disease and dementia risk is one event reported by 7 outlets, and this page does not rate the story as biased or unbiased. What it publishes is the spread: which outlets ran it, where named rating organisations place each of them on the spectrum, and what each side chose to lead with. A leaning rating describes an outlet's record over time, not this article, and the two should not be run together.
Which outlets covered Shingrix vaccine may reduce heart disease and dementia risk?
7 that we know of, every one of them listed further up this page with a link to its own report and to what we hold on the publisher. Nothing here is a summary of somebody else's summary: the outlets are named so the original reporting can be read.
What is the potential cardiovascular benefit of the Shingrix vaccine?
A study suggests the Shingrix vaccine may offer a nine percent reduction in cardiovascular disease burden over seven years compared to the older Zostavax vaccine. Specific reductions included 10% for coronary heart disease, 12% for heart failure, and 7% for atrial fibrillation.
How does Shingrix potentially reduce dementia risk?
One analysis linked the Shingrix vaccine to a 24% lower risk of dementia in older adults. Researchers are exploring whether the vaccine's AS01 adjuvant may produce temporary, beneficial changes in innate immune cells and the vascular endothelium.
When was the cardiovascular benefit of Shingrix most apparent?
The apparent cardiovascular benefit of Shingrix emerged mainly in the first 3.5 years after vaccination and then weakened. This suggests the immune changes may be time-limited.

Read it at the source

7 outlets, grouped by the leaning a published rating gives them. Every headline links to the original; an underlined outlet name opens our profile of that publisher.

How did this read?

About the coverage, not about the story. We do not ask whether you agree with what happened — we have no honest use for that answer.

Shingrix Vaccine Benefits | MediaBias News